cardiorenal syndrome
Conditions
Interventions
1:zhenwutang decotion
2:placbo
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) aged 18-85 years, male or female; (2) accord with the diagnostic criteria of chronic heart failure, and have a history of chronic heart failure of more than 3 months or clinical symptoms of heart failure for more than 3 months; (3) color doppler echocardiography showed that left ventricular ejection fraction (LVEF) was less than 50% (modified Simpson method); (4) NYHA cardiac function classification ? ~ IV (hemodynamic stability and no need for intravenous administration); (5) the content of serum NT-proBNP was = 450 PG = ml; (6) those who received standardized drug treatment for at least 2 weeks without adjusting the dosage and intravenous therapy.
Exclusion criteria
Exclusion criteria: (1) patients scheduled for coronary artery revascularization within 12 weeks, cardiac resynchronization therapy or cardiac resynchronization therapy within 12 weeks; (2) patients with tumor, severe neuroendocrine system diseases and psychosis; (3) patients with left ventricular outflow tract obstruction, myocarditis, hypertrophic cardiomyopathy, restrictive cardiomyopathy, large aneurysms, arterial dissection, congenital heart disease and unrepaired hemodynamic changes; (4) uncontrolled hypertensive patients with systolic blood pressure = 180/mmHg and / or diastolic blood pressure = 110 mmHg; (5) pregnant or preparing for pregnancy and lactation; (6) allergic constitution, or those who are known to be allergic to therapeutic drugs; (7) patients preparing for renal replacement therapy in the near future; (8) 1 months to participate in other drug clinical researchers; (9) According to the researcher's judgment, the patient was unable to complete the study or was unable to comply with the requirements of the study (for managerial or other reasons).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT-proBNP;Creatinine; | — |
Countries
China
Contacts
Public ContactFu Qiang
Zhujiang Hospital, Southern Medical University
Outcome results
None listed