Type 2 diabetes
Conditions
Interventions
test group :intensive treatment group+empagliflozin
control group:intensive treatment group
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? Aged 18 to 70 years, gender is not limited; ? 18 kg/m2=BMI=35 kg/m2; ? Patients diagnosed with type 2 diabetes according to WHO criteria (1999); ? At screening, newly diagnosed patients with glycosylated hemoglobin (HbA1c) > 9% or fasting blood glucose (FBG) = 11.1 mmol / L;Or HbA1c >7% after oral administration; ? Patients volunteered to participate in the trial and signed informed consent; ? Patients are able to communicate well with the investigator and comply with the entire trial requirements.
Exclusion criteria
Exclusion criteria: The patient has developed diabetic ketoacidosis, non-ketotic hyperosmolar coma, severe infection (especially urinary tract infection), acute cardiovascular and cerebrovascular accident, severe liver and kidney dysfunction in the past 6 months and other diseases that researchers disagree to enroll.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1,5 anhydroglucitol;Glycosylated serum albumin;Venous fasting blood glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum blood sugar fluctuation;Average blood sugar;Standard deviation of blood glucose levels;Average blood glucose fluctuation;Average absolute difference in blood glucose during the day;Xieqing huóxìng yang 5/5000 Serum reactive oxygen species;Malondialdehyde;Superoxide dismutase;Hypersensitive C-reactive protein;Tumor necrosis factor-a;IL-6; | — |
Countries
China
Contacts
Public ContactLihui Zhang
The Second Hospital of Hebei Medical University
Outcome results
None listed