Hepatocellular carcinoma (HCC)
Conditions
Interventions
Gold Standard:Histological findings or MRI features
Index test:Sonazoid-contrast 
ultrasound 
(S-CEUS)
Sponsors
Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients will be eligible for the study if they fulfill all of the followings criteria: 1) they are at least 18 years old; 2) with known chronic liver disease and liver cirrhosis; 3) On ultrasonography, their liver shows nodular liver parenchyma; 4) For chronic hepatitis B patients, their LSM-HCC score should be =11 (factors and scores please refer below) OR for other chronic liver diseases, the liver stiffness measurement (LSM) of the patients should be =12.0 kPa; and 5) All the patients must agree to participate in the study with informed written consent. Factors and their respective scores of LSM-HCC score (11) are listed below. 1. Age [>50 years, score +10] and [age 50 or less, score 0]; 2. Albumin [35g/l or less, score +1] and [albumin > 35g/l, score 0]; 3. HBV DNA [> 200,000 IU/ml, score +5] and [200,000 IU/ml or less, score 0]; 4. Liver stiffness measurement [8.0 kPa, score 0], [ 8.1-12.0 kPa, score +8] and [> 12.0 kPa, score +14]. *Total score ranges from 0 to 30. HBV = hepatitis B virus.
Exclusion criteria
Exclusion criteria: 1. Child-Pugh score 8 or above; 2. Previous or current hepatocellular carcinoma; 3. Portal vein thrombosis; 4. Previous liver surgery; 5. Liver transplantation; 6. Contraindications to transient elastography (e.g. pregnancy, previous pacemaker implantation); 7. Contraindications to Sonazoid contrast; 8. Contraindications to Primovist contrast; 9. Contraindications to magnetic resonance imaging (e.g. metallic implants, pacemaker implantation); 10. Refusal to consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| detection of small HCC 2cm or smaller; | — |
Secondary
| Measure | Time frame |
|---|---|
| detection of HCC larger than 2.0cm; | — |
Countries
China
Contacts
Public ContactCho Chi Min, Carmen
Prince of Wales Hospital, CUHK
Outcome results
None listed