Effects of different dosages of sufentanil on cardiovascular response and stress response induced by rapid sequence induce and intubation

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900022378

Enrollment

Unknown

Registered

2019-04-08

Start date

2019-04-10

Completion date

Unknown

Last updated

2019-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients underwent rapid sequence induce and intubation.

Interventions

S0.1:sufentanil 0.1µg/kg

S0.2:sufentanil 0.2µg/kg

S0.3:sufentanil 0.3µg/kg

NS:normal saline

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Aged 18 to 50 years; ASA I and II; BMI18.5-28 kg/m2; Preoperative blood pressure and blood volume were normal; Patients underwent rapid sequence induce and intubation.

Exclusion criteria

Exclusion criteria: Anticipated difficult airway; Severe cardiopulmonary disease;Severe hepatorenal dysfunction; Severe endocrine diseases; Opioid-dependent patients; Contraindications to induced drugs; Preoperative use of cardiovascular drugs; Pregnancy; Mental incompetence.

Design outcomes

Primary

Measure	Time frame
blood pressure;heart rate;Left ventricular end-diastolic volume;Left ventricular end-systolic volume;stroke volume;cardiac outpu;Left ventricular end-diastolic diameter;Left ventricular end-systolic diameter;ejection fraction;plasma catecholamine concentration;	—

Secondary

Measure	Time frame
Intubation conditions;OAA/S grade;Intubation time;	—

Countries

China

Contacts

Public ContactFaping Tu

Affiliated Hospital of North Sichuan Medical College

tfpnc@163.com+86 13808270833

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026