chronic insomnia
Conditions
Interventions
control group:No
Experimental group 1:Repeated transcranial magnetic stimulation intervention
Experimental group 2:Pseudo-intervention of repetitive transcranial magnetic stimulation
Sponsors
Beijing Friendship Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Chronic insomnia group (1) Diagnosis of chronic insomnia in accordance with DSM-V. (2) PSQI greater than 7. (3) Aged 50 to 80 years. (4) Subjects have been educated for more than 6 years and have the ability to complete the cognitive function tests and other tests prescribed by the program. (5) Sign the informed consent. Control group (1) There are no complaints about the quality or quantity of sleep. (2)PSQI less tha 7. (3) Aged 50 to 80 years. (4) Subjects have been educated for more than 6 years and have the ability to complete the cognitive function tests and other tests prescribed by the program. (5) Sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Alcohol and drug dependence or abuse in the past. (2) Patients with severe or unstable organic diseases (including severe heart, liver and kidney diseases, tumors, etc.). (3) According to the diagnostic criteria of depression and anxiety disorder, Hamilton Depression Scale (HAMD) (17 items) greater than 17 points and Hamilton Anxiety Scale (HAMA) greater than 14 points. (4) Patients with dementia diagnosed at baseline (e.g. Alzheimer's disease, Parkinson's disease, Lewy body dementia, frontotemporal lobe dementia). (5) A clear history of cerebrovascular stroke, with definite symptoms and signs of neurological deficits at the time of onset, and corresponding lesions left by neuroimaging. (6) Severe white matter lesions, Fazekas score greater than 3; key sites such as hippocampus, angular gyrus, cingulate gyrus, lacunar infarction of thalamus. (7) Neurological diseases that can cause cognitive impairment, such as brain trauma, epilepsy, encephalitis, hydrocephalus, brain tumors, etc. (8) Cognitive impairment caused by severe liver and kidney insufficiency, endocrine diseases and vitamin deficiency. Abnormal laboratory indicators: moderate anemia, fasting blood sugar more than 2 times the normal upper limit, Cr more than 1.5 times the normal upper limit, liver function (AST or ALT) more than 2 times the normal upper limit. (9) Sleep disorders caused by jet lag and shift work. (10) The medial temporal lobe atrophy visual rating scale (MTA) greater than 2 points on one side and/or greater than 5 points on both sides. (11) Systolic blood pressure more than 180 mmHg or less than 90 mmHg, diastolic blood pressure more than 120 mmHg or less than 60 mmHg during screening. (12) Take drugs to improve cognitive function, such as donepezil, galantamine, kabalatin, memantine and so on. Take drugs that have negative effects on cognitive function, such as anticholinergic drugs, antipsychotic drugs, antiepileptic drugs, corticosteroid and so on.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA;EEG and Event-related Potential; | — |
Secondary
| Measure | Time frame |
|---|---|
| AVLT;Boston named test;WAIS Digital Width Test;trail making test;ComplexFigureTest;(Mini-mental State Examination;Pittsburgh sleep quality index;Insomnia Severity Index;Hamilton Anxiety Scale;Hamilton Depression Scale;International Physical Activity Scale(Short Volume);Functional activities questionnaire;Beck Scale for Suicide Ideation; | — |
Countries
China
Contacts
Public ContactYongbo Zhang
Outcome results
None listed