Amantadine Effects in Patients with Chronic Disorders of Consciousness

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900022352

Enrollment

Unknown

Registered

2019-04-07

Start date

2019-04-08

Completion date

Unknown

Last updated

2019-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Disorders of Consciousness

Interventions

Case series:Amantadine

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Selection of long-term coma patients over 3 months due to trauma or vascular accident (18 to 60 years old)

Exclusion criteria

Exclusion criteria: 1. Exclude patients with severe drug responses. 2. Do not rule out long-term visitors. 3. Exclusion of children under 14 years of age 4. Rule out those who cannot comply with the instructions for normal withdrawal and rational use of drugs. 5. Exclude patients with severe heart disease and liver and kidney dysfunction. 6. Patients with severe coagulation abnormalities were excluded. 7. Those who have recurrent seizures are excluded (or those with recurrent epilepsy or status epilepticus in medication will be withdrawn from the trial).

Design outcomes

Primary

Measure	Time frame
JFK Coma Recovery Scale-Revised;	—

Secondary

Measure	Time frame
Glasgow Outcome Scale;plasma proteins;	—

Countries

China

Contacts

Public ContactYi Dai

Neurosurgery Department, Yijishan Hospital, Wannan Medical College

yjsyy0775@163.com+86 13966006108

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026