Alzheimer disease
Conditions
Interventions
normal aged group:none
AD-sham-DBS group:sham-DBS
AD-DBS group:DBS
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: Normal elderly group: 1. Aged 55-80 years. 2. No cognitive impairment. 3. The Mini Mental State Examination (MMSE) score is not lower than the corresponding cultural level limit. AD-sham-DBS group and AD-DBS group: 1. Aged 55-80 years. 2. Conforms to the National Institute of Neurology, Communication Disorders and Stroke - Alzheimer's Disease and Related Diseases Association (NINCDS-ADRDA), the most likely diagnostic criteria for AD (1984). 3. Cognitive impairment: MMSE total score = 26 points. 4. CDR 0.5-2. 5. Diagnostic evidence of memory loss, memory loss for at least 6 months, and a progressive trend. 6. Stable use medication before screening for =3 months, and no plan to change medication within 12 months after randomization. 7. Signing informed consent.
Exclusion criteria
Exclusion criteria: Normal elderly group: 1. Have had nervous system diseases (including stroke, optic neuromyelitis, Parkinson's disease, epilepsy, etc.). 2. There are infections that can affect brain function (eg HIV, viral or bacterial meningitis/encephalitis). 3. Suffering from intracranial tumors or related medical history (eg, glioma and meningioma). 4. MRI scan contraindications. 5. The investigator believes that the subject is unlikely to complete the study. AD-sham- DBS Group and AD- DBS Group 1.Dementia caused by other causes: vascular dementia, central nervous system infections (such as AIDS, syphilis, etc.), Creutzfeldt-Jakob disease, Huntington's disease and Parkinson's disease, Lewy body dementia, traumatic dementia, and other physical and chemical factors (such as drug poisoning, alcoholism, carbon monoxide poisoning, etc.), important physical diseases (such as hepatic encephalopathy, pulmonary encephalopathy, etc.), intracranial space-occupying lesions (such as subdural hematoma, brain tumors), endocrine system diseases (such as thyroid disease, parathyroid disease) or dementia caused vitamin deficiency or any other cause. 2. There are infections that can affect brain function (eg HIV, viral or bacterial meningitis/encephalitis). 3. Suffering from intracranial tumors or related medical history (eg, glioma and meningioma). 4. Suicide risk. 5. MRI scan contraindications. 6. The investigator believes that the subject is unlikely to complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's disease-related scale;Mental Behavior Rating Scale;Quality of life related scales;MRI data;PET-CT data;Scalp EEG; | — |
Countries
China
Contacts
Public ContactZhang Jianguo
Outcome results
None listed