autoimmune refractory epilepsy
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1 Patients with refractory epilepsy (more than 4 episodes per month, 2 drugs are ineffective). 2 Aged = 1 year and <70 years. 3 Mainly includes the following several types of autoimmune epilepsy: (1) Primary autoimmune epilepsy: Rasmussens encephalitis encephalitis; (2) Immunotherapy reactive epilepsy: infantile spasm, Landau–Kleffner syndrome; (3) Systemic autoimmune diseases associated with epilepsy: systemic lupus erythematosus, celiac disease, Sj ogren syndrome, linear scleroderma, others; (4) Antibody-mediated epilepsy: Hashimoto's encephalopathy (autoimmune encephalopathy associated with thyroid antibodies), glutamate decarboxylase GAD-65 antibody-related encephalitis and seizures, NMDA receptor antibody-related encephalopathy, voltage Gated potassium channel-complex antibody-related encephalitis epilepsy.
Exclusion criteria
Exclusion criteria: 1. The following epileptic patients with a clear cause: cerebrovascular malformations, focal cerebral cortical developmental disorders, traumatic, cerebrovascular accident sequelae, epilepsy with known genetic mutations (including some common hereditary idiopathic epilepsy) . 2. Those who participate in other clinical trials or researchers believe that it is not appropriate to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency of Seizure;Brain wave; | — |
Countries
China
Contacts
Public ContactDeng Yuhong
Outcome results
None listed