acute intracranial atherosclerotic vascular occlusion
Conditions
Interventions
Treatment group:tirofiban hydrochloride injection
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age = 18 years; 2) the (mRS) score of modified Rankin scale before stroke was 0 or 1; 3) Intracranial hemorrhage, subarachnoid hemorrhage and space occupying were excluded by cranial CT; 4) intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) within 4.5 hours and mechanical thrombectomy (through inguinal puncture) within 6 hours after onset, and intracranial atherosclerotic macrovascular occlusion was confirmed during the operation. 5) the subject (or the legal representative of the subject) signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1) there was a tendency of severe bleeding, intracranial hemorrhage or extracranial hemorrhage and active digestive tract ulcer in the past three months; 2) platelet count <100 × 10^9 /L; 3) hematological diseases; 4) patients with malignant tumor or other critically ill diseases; 5) cranial CT showed early and definite large area cerebral infarction of anterior circulation; 6) hypersensitivity to contrast medium; 7) lactating or pregnant women; 8) malignant hypertension without good control; 9) the degree of vascular distortion, variation and stenosis is serious and can not be operated; 10) end-stage disease, expected survival < 90 days, or expected inability to complete follow-up; 11) patients with severe injury and surgical history within 3 months; 12) those who are allergic to the study of drugs or drugs with similar chemical structures; 13) participated in other clinical trials or clinical study participants within 3 months prior to the start of this study; 14) the researchers do not consider it appropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of vascular re-occlusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day functional prognosis;Incidence of deterioration of neurological function within 24 hours; | — |
Countries
China
Contacts
Public ContactDezhi Liu
Department of Neurology, Shanghai General Hospital
Outcome results
None listed