Neonatal cholestasis
Conditions
Interventions
1:Oral Bifidobacterium
2:Routine feeding without Bifidobacterium
Sponsors
Children's Hospital Affiliated to Soochow University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: (1) admission to hospital within 12 hours after birth; (2) gestational age ranging from 28–34 weeks; (3) very low birth weight (<1500 g); (4) total parenteral nutrition (TPN) 1 day following birth.
Exclusion criteria
Exclusion criteria: (1) congenital heart diseases, malformations in the gastrointestinal tract, and genetic metabolic diseases; (2) surgical treatment during hospitalization; (3) severe symptoms of digestive diseases (e.g., vomiting, abdominal distention, and diarrhea) before TPN; (4) cholestasis at the time of admission to our hospital; (5) taking gastrointestinal stimulants; (6) taking antibiotics; (7) incompletion or withdrawal of treatment during hospitalization.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Total intestinal feeding time;Exhaust time;Recovery time to birth weight;Hospital days; | — |
Primary
| Measure | Time frame |
|---|---|
| Bile siltation;Bile silting liver damage;septicaemia;Necrotizing enterocolitis;Feeding intolerance;Growth retardation outside the palace;Total bilirubin;Direct bilirubin;Gamma glutamine transferase;Alkaline phosphatase;Total bile acid;Total cholesterol; | — |
Countries
China
Contacts
Public ContactWu Gaohong
Children's Hospital Affiliated to Soochow University
Outcome results
None listed