Individually-tailored intervention strategy and risk staging prognostic system for progression from mild cognitive impairment to alzheimer's disease

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900022287

Enrollment

Unknown

Registered

2019-04-03

Start date

2019-04-03

Completion date

Unknown

Last updated

2019-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mild cognitive impairment

Interventions

Group 1:real rTMS interventions

Group 2:Pseudo rTMS Interventions

Group 3:real rTMS and cognitive training interventions

Group 4:Pseudo rTMS and cognitive training interventions

Group 5:Cognitive training interventions

Placebo group:Placebo

Contol group:No intervention

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. subjective memory impairment corroborated by the subject and an informant; 2. objective memory performance documented according to an Auditory Verbal Memory Test-delayed recall score that was within = 1.5 SD of age- and education-adjusted norms (the cutoff was = 4 correct responses on 12 items for = 8 years of education); 3. normal general cognitive function as evaluated by a MMSE of 24 or higher; 4. a Clinical Dementia Rating of 0.5, with at least a 0.5 in the memory domain; no or minimal impairment in daily living activities.

Exclusion criteria

Exclusion criteria: 1. a past history of known stroke (modified Hachinski score of > 4), alcoholism, head injury, Parkinsons disease, epilepsy, major depression (excluded by Self-Rating Depression Scale), or other neurological or psychiatric illness (excluded by clinical assessment and case history); 2. major medical illness (e.g., cancer, anemia, and thyroid dysfunction); 3. severe visual or hearing loss; 4. T2-weighted MRI showing major white matter (WM) changes, infarction, or other lesions (two experienced radiologists analyzed the scans); 5. dementia meets the criteria of the National Institute of Neurological and Communicative Disorders and Stroke or the AD and Related Disorders Association criteria for AD.

Design outcomes

Primary

Measure	Time frame
MoCA;MMSE;CDR;ADAS;MDRS;CARE index;Functional connectivity;Gray Matter;White matter integrity;Functional Network;Hippcampus;Structural Network;	—

Countries

China

Contacts

Public ContactJiu Chen

the Affiliated Brain Hospital of Nanjing Medical University

ericcst@aliyun.com+86 18751997338

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026