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Diurnal Variations of Peripapillary and Macular Vessel Density in Patients with Primary Open-angle Glaucoma and healthy subjects using Optical Coherence Tomography Angiography

Diurnal Variations of Peripapillary and Macular Vessel Density in Patients with Primary Open-angle Glaucoma and healthy subjects using Optical Coherence Tomography Angiography

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900022276
Enrollment
Unknown
Registered
2019-04-02
Start date
2019-04-08
Completion date
Unknown
Last updated
2019-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Interventions

POAH Group:None
Healthy Group:None

Sponsors

Beijing Tongren Hospital, Capital Medical University, Beijing, China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Common inclusion criteria for both POAG and healthy groups were best-corrected visual acuity=20/40, and a refractive error between -3 and +3 diopters. Common exclusion criteria for both groups were presence of any other intraocular disease; inability to fixate; significant media opacity preventing adequate image quality; previous intraocular surgery. Inclusion criteria for healthy subjects were: (1) diurnal IOP=21 mm Hg with no history of elevated IOP; (2) normal-appearing optic disc and intact neuro-retinal rim from fundus photographs; (3) average and quadrant RNFL thickness within 99% confidence limits; and (4) a minimum of two reliable normal VFs, defined as a PSD within 95% confidence limits and a GHT result within normal limits. Inclusion criteria for patients with POAG were: (1) an open iridocorneal angle on gonioscopy; (2) glaucomatous abnormalities of the optic disc, such as notches in neuro-retinal rim and localized or segmental loss of the retinal nerve fiber layer; (3) repeatable glaucomatous VF damage defined as a GHT result outside normal limits and a PSD outside 95% normal limits.

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

MeasureTime frame
Peripapillary Vessel Density;Intraocular pressure;

Secondary

MeasureTime frame
Blood pressure;Pulse rate;

Countries

China

Contacts

Public ContactLi Shuning

Beijing Tongren Hospital, Capital Medical University, Beijing, China

lishuningqd@163.com+86 13241802936

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026