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Correlation Between Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota and Nonalcoholic Fatty Liver Disease

Correlation Between Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota and Nonalcoholic Fatty Liver Disease

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900022263
Enrollment
Unknown
Registered
2019-04-02
Start date
2019-03-31
Completion date
Unknown
Last updated
2019-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonalcoholic Fatty Liver Disease

Interventions

Control group and disease group:no

Sponsors

TONGDE Hospital Of Zhejiang Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 70 Years

Inclusion criteria

Inclusion criteria: Liver pathology and imaging changes are similar to alcoholic liver disease, but there are no other reasons for excessive liver fat, such as overnutrition, obesity and metabolic syndrome. Non-alcoholic: history of drinking or no excessive drinking [eating alcohol (alcohol) per week for the past 12 months, male < 210 g, female <140g], no amiodarone, methotrexate, tamoxifen, Glucocorticoids and other drugs. Exclude specific diseases that can lead to fatty liver such as genotype 3 HCV infection, hepatolenticular degeneration, autoimmune hepatitis, total parenteral nutrition, deprived beta lipoproteinemia, congenital lipid atrophy, celiac disease and so on.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating women; 2. psychotic patient; 3. Patients with severe,uncontrolled organic lesions or infection, such as decompensated heart, lung, kidney failure can lead to tolerance of chemotherapy; 4. Immune dysfunction , such as HIVaplastic anemialeukemiaetc; 5. using other experimental drugs or paticipate in other clinical trials at the same time.

Design outcomes

Primary

MeasureTime frame
Tryptophan;kynurenine;indole acetic acid;

Countries

China

Contacts

Public ContactLiu Xinying

TONGDE Hospital Of Zhejiang Province

liu-xinying@foxmail.com+86 18158440186

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026