bronchiectasis
Conditions
Interventions
Local treatment group:Intraoperation of dexamethasone and gentamicin under tracheoscope + Basic treatment
Routine treatment group:Basic treatment
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Non-cystic fibrotic bronchiectasis confirmed by chest CT or HRCT; 2. To meet the diagnostic criteria for acute exacerbation of bronchiectasis, see Annex 3 for details. 3. Aged 18 years and above, male or female; 4. Accord with the indication of bronchoscopy without contraindication. 5. When fully informed of the purpose, method and possible discomfort of the test, consent and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. The drug was administered with prednisolone or equivalent systemic corticosteroids for more than 14 days within 4 weeks before administration; 2. Patients allergic to dexamethasone and gentamicin; 3. Patients with malignant tumors; 4. Patients with tractive bronchiectasis, cystic pulmonary fibrosis, active pulmonary tuberculosis, fungal infection, active sarcoidosis, allergic bronchopulmonary aspergillosis (ABPA), acute attack of asthma, dry bronchiectasis and bronchiectasis have hemoptysis more than 100 ml per day, hypogammaglobulinemia or common variants. Immunodeficiency disease (CVID), bronchiectasis caused by foreign body inhalation; 4. Those with serious other systemic diseases and organ dysfunction; 5. Pregnancy, lactation, recent family planning and failure to take effective contraceptive measures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Indicators of clinical efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life;Chest CT;Sputum culture;pulmonary function; | — |
Countries
China
Contacts
Public ContactHuiping Li
Shanghai Pulmonary Hospital Tongji University, School of Medicine
Outcome results
None listed