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Preliminary observation on the efficacy and safety of Nocardia Rubra Cell Wall Skeleton in the treatment of oral erosion lichen planus: a randomized, double-blind, controlled trial

Preliminary observation on the efficacy and safety of Nocardia Rubra Cell Wall Skeleton in the treatment of oral erosion lichen planus: a randomized, double-blind, controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900022245
Enrollment
Unknown
Registered
2019-03-31
Start date
2019-04-01
Completion date
Unknown
Last updated
2019-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral erosive lichen planus

Interventions

1:freeze-dried powder contain Nr-CWS
2:freeze-dried powder contain no Nr-CWS

Sponsors

Peking University Hospital Of Stomatology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. A subject diagnosed as an erosive oral lichen planus based on medical history, clinical manifestations, and/or pathological findings; 2. The age of onset is 18 to 65 years old, and the relevant treatment is not taken for this disease; 3. Patients who agree and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Conmbined with other identified oral mucosal diseases; 2. With systemic serious systemic diseases; 3. Patients with uncontrolled and stable hypertension, heart disease, diabetes and tumors; 4. Those who have used antibiotics within 3.1 months and have used immunologic preparations within 3 months; 5. Certain drugs or amalgam fillings may cause mossy-like reactions; 6. Pregnant women, lactating women; 7. Allergies and a history of allergies to drugs and food.

Design outcomes

Primary

MeasureTime frame
Visual analogue scale;

Countries

China

Contacts

Public ContactHua hong

Department of Mucosa, Peking University Hospital Of Stomatology

honghua1968@aliyun.com+86 010-82195226

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026