Acquired immunodeficicency syndrome and acute respiratory failure
Conditions
Interventions
HFNC group:High-Flow Nasal Oxygen Cannula
Sponsors
Beijing Ditan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. AIDS diagnosis evidenced by at least one of the items below: HIV antibody is positive by west-block test or HIV RNA is positive by PCR, participants admitted to the ICU or to the infection disease department with acute respiratory failure; 2. Aged 18 to 70 years; 3. Use of accessory muscles, paradoxical breathingtachypnea greater than 25/min; 4. Patients with non-hypercapnic ARF: (1) PaO2 / FiO2 ratio 90%; (3) Blood gas analysis with PaCO2 = 50 mmHg. 5. Course of ARF after admission to our hospital less than 72 hour; 6. Agree to paticipate in this study and undergo tracheal intubation.
Exclusion criteria
Exclusion criteria: 1. Patients with ARF who have: Indication of emergency endotracheal intubation; 2. Anatomical factors precluding the use of a nasal cannula; 3. Hypercapnica indication NIV (PaCO2 =50 mmHg); 4. Presence of pneumothorax or extensive pleural effusion; 5. Cardiorespiratory arrest; 6. Isolated cardiogenic pulmonary edema indicating NIV; 7. Decreased level of consciousness (Glasgow 0.3 microg/kg/min or equivalent; 9. Patients with other known immunosuppression, defined as use immunosuppressant drugs, solid organ transplantation, solid tumor required chemotherapy in the last 5 yearshematologic malignancy regardless of time since diagnosis and received treatmentor primary immune deficiency; 10. Surgery with in the last 6 days; 11. Pregnancy or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endotracheal intubation rate [ Time Frame: 14 days ]; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality [ Time Frame: 28 days ];Mortality [ Time Frame: 90 days ]; | — |
Countries
China
Contacts
Public ContactAng Li
Capital Medical University, Beijing Ditan Hospital
Outcome results
None listed