gastric carcinoma
Conditions
Interventions
single arm:preoperative chemotherapy (Docetaxel, Oxaliplatin and Xeloda) +operation+postoperative chemotherapy
Sponsors
Sichuan Cancer Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years, male or female. 2. Pathologically confirmed gastric cancer or gastroesophageal junction adenocarcinoma, not signet -ring cell carcinoma. 3. ECOG(Eastern Cooperative Oncology Group ) 0-1. 4. T 3-4. 5. CT showed swelling lymph nodes, not bulky lymph node or N3(paraaortic). 6. No evidence of distant metastasis by CT; gastric cancer were able to resectable lesions. 7. Esophageal invasion greater than 3cm by endoscopy or X-ray; Not invade pancreatic head. 8. No peritoneal metastasis and CY0 by laparoscopy. 9. No prior chemotherapy or radiotherapy in 5 years. 10. Sufficient oral intake. 11. Available Organ function: Neutrophils=1.5x10^9/L; Hemoglobin >8g/L; Blood platelet =90x10^9/L; alanine transaminase / Aspertate aminotransferase=2.5 upper limit of normal range (ULN); serum creatinine=1.5 pper limit of normal range (ULN), Serum albumin=30g/L. 12. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Active multiple cancer. 2. Infectious disease. 3. Other severe complications such as ileus, intensitinal pneumonitis, pulumonary fibrosis, or ischemic heart disease 4. Probable pregnancy, and the period of lactation. 5. Difficulty to join the trial due to psychosis or psychotic symptoms. 6. Not fit to the protocol treatment by the physicion's dicision.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3 year survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| treatment response rate;R0 resect rate;proportion of completion of treatment;disease relapse-free survival; | — |
Countries
China
Contacts
Public ContactShuomeng Xiao
Outcome results
None listed