Impaired VitD metabolism in AIS

Uncovering the effect of CYP27B1 on osteoblasts functional activity and its link to bone quality and curve progression in Adolescent Idiopathic Scoliosis – An in vitro and transgenic mice model study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900022210

Enrollment

Unknown

Registered

2019-03-30

Start date

2020-01-01

Completion date

Unknown

Last updated

2019-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adoloscent Idiopathic Scoliosis

Interventions

10 non-AIS subjects:biopsy and blood-taking

10 AIS patients:Bone biopsy and blood-taking

Eligibility

Sex/Gender

Female

Age

11 Years to 18 Years

Inclusion criteria

Inclusion criteria: 10 Chinese girls with ages between 11 and18 years old with newly or retrospectively diagnosed AIS will be recruited.

Exclusion criteria

Exclusion criteria: (1) congenital scoliosis; (2) neuromuscular scoliosis; (3) scoliosis of metabolic etiology; (4) scoliosis with skeletal dysplasia; (5) scoliosis with known endocrine and connective tissue abnormalities.

Design outcomes

Primary

Measure	Time frame
Maximal Cobb angle;Serum VitD and 1,25(OH)2D levels;Bone mineral density with DXA;	—

Countries

China

Contacts

Public ContactProf. Wayne, Yuk Wai LEE

The Chinese University of Hong Kong

waynelee@ort.cuhk.edu.hk+852 37636154

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026