Acute exacerbation of chronic obstructive pulmonary disease
Conditions
Interventions
1:Standard treatment group
2:Routine treatment of Western medicine plus traditional Chinese medicine
3:"Drinking inside and irradiating outside" plus standard treatment group
4:Traditional Chinese Medicine, Internal Drinking and External Illumination + Standard Treatment Group
Sponsors
Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
19 Years to 80 Years
Inclusion criteria
Inclusion criteria: AEC0PD diagnostic criteria refers to the Chinese Experts Consensus on AECOPD Diagnosis And Treatment (revision 2017) ?The diagnosis of AECOPD is completely dependent on clinical manifestations that sudden changes in the chief symptoms (dyspnea, cough, and/or coughing phlegm) exceed the range of daily variation; ?AECOPD is a clinically excluded diagnosis. Clinical and/or laboratory tests exclude other specific diseases that can explain sudden changes in these symptoms. The diagnosis of AECOPD needs to meet ?? or ??? in (1), and ?? in (2). Traditional Chinese medicine (TCM) syndrome diagnostic criteria The TCM diagnosis of phlegm block and lung obstruction refers to the TCM Syndrome Diagnostic Criteria on AECOPD (2011) (1) Phlegm block and lung obstruction ? Coughing or gasping, short of breath ? Phlegm syndrome; ? Stomach fullness; ? Sticky mouth, dementia or lack of appetite; ? Greasy tongue,slippery pulse. The diagnosis depends on 3 symptoms from ???, and 1 symptom from ??. (2) Blood stasis as the accompanying symptom ? Dark purple in face color; ? Purple lips; ? Dark purple tongue with freckle or blemish; ? Distorted sublingual collaterals; The diagnosis depends on 1 symptom from ????. The phlegm block and lung obstruction syndrome matches with 3 symptoms from (1), as well as with 1 symptom from (2). The diagnosis was verified by 2 Chinese medicine practitioners back-to-back. Inclusion criteria (1) It conforms to the diagnostic criteria of Western medicine and traditional Chinese medicine; (2) Age: 19 =age=80 years old; (3) COPD was diagnosed for more than one year, and COPD grade in stable phase was GOLD 2017 standard grade 2 or 3 (50% less than FEV1 9.5 x 10^9/L); (7) The patients or their legal representatives understand and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Organ dysfunction parameters: oxygenation index (PaO2/FiO2) 44.2 micromol/L); coagulation dysfunction (international normalized ratio > 2.5 or activated partial thromboplastin time > 60 s); intestinal paralysis: disappearance of bowel sounds; thrombocytopenia ( 70 mmol/L); (2) Tissue perfusion parameters: hyperlactemia (>3 mmol/L); prolonged capillary refilling time or skin spots; (3) Pulmonary diseases such as pulmonary interstitial fibrosis and bronchiectasis; (4) Any hematological neoplasms (5) Heart failure (NYHA-IV); (6) Patients who need mechanical ventilation as an adjunct treatment; (7) Positive urinary pregnancy test; (8) Known or suspected to be allergic to the components of traditional Chinese medicine compound used in our institute; (9) When the local skin of the irradiated area is damaged and the patient's skin is sensitive to heat, skin allergy or skin sensory disturbance may occur. (10) Those with heart pacemaker or other medical electronic instruments embedded in the body; (11) Those whose body temperatures have been above 39.5? for 3 consecutive days or more, active pulmonary tuberculosis, severe suppurative diseases; (12) Those who have participated in other clinical studies in the past three months; (13) Those who are determined by the researchers not suitable to take part in the study group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood routine + CRP;Procalcitonin;blood gas analysis;pulmonary function;Lung CT; | — |
Countries
China
Contacts
Public ContactLi Yan
Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine
Outcome results
None listed