persistent pulmonary hypertension of the new-born
Conditions
Interventions
Sponsors
Wuhan Children's Hospital, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients with PPHN confirmed by clinical and ultrasonographic diagnosis and requiring endotracheal intubation and ventilator-assisted ventilation; (2) gestational age(GA) >37 weeks old and birth weight(BW) >2500 grame with a birth age of less than 24 hours; (3) Parents signed informed consent, agreed to participate in the study and accepted randomized grouping.
Exclusion criteria
Exclusion criteria: (1) Congenital respiratory malformations, such as Pierre-Robin syndrome, congenital laryngeal softening, etc.; (2) obvious congenital malformations or chromosomal diseases (complete cleft palate, trisomy 21, trisomy 18, etc.); (3) those who had pulmonary hemorrhage or air leakage before admission; (4) Complex congenital heart disease; (5) Class III-IV intracranial hemorrhage; (6) Pulmonary alveolar capillary dysplasia complicated with PPHN.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood gas analysis;Ventilator parameters;oxygen index;the time of ventilation;pulmonary artery pressure;the incidence of complication;Gesell score; | — |
Secondary
| Measure | Time frame |
|---|---|
| the incidence of VAP; | — |
Countries
China
Contacts
Public ContactZeng Lingkong
Wuhan Children's Hospital, Huazhong University of Science and Technology
Outcome results
None listed