chronic wounds
Conditions
Interventions
control group:negative pressure wound therapy
treatment group:topical continuous delivery of non-pressurised oxygen combined with negative pressure wound therapy
Sponsors
Wound Care Center of Outpatient Department, Eastern Theater General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Chronic wounds with full cortical damage caused by various reasons (duration = 30d ), specifically including pressure injury, ulcerative wound, diabetic foot, surgical incision, traumatic wound, etc.; 2) Area = 8cm2, depth = 2cm; 3) Aged = 18 years, gender and region are not limited; 4) Patients or their families informed consent and volunteered to participate in the study.
Exclusion criteria
Exclusion criteria: 1) Malignant wounds; 2) Antibiotics are needed for systemic infections; 3) Bleeding tendency and coagulopathy; 4) Accompany with untreated osteomyelitis; 5) Accompany with nerves exposed,blood vessels exposed or active bleeding at the wound; 6) The wound is accompanied by necrotic tissue (the wound base is yellow or black) but there are debridement contraindications or inability to debride; 7) Systemic comorbidities affecting wound healing such as malnutrition, autoimmune diseases, advanced tumors, multiple organ failure, unstable blood sugar control, etc.; 8) Using steroid hormones, immunosuppressants, chemotherapeutics, etc. to affect wound healing drugs; 9) The wound can not form a closed environment; 10) Patients who have participated in other clinical trials within 3 months prior to the trial (including the interventions in this trial); 11) Sponsors or researchers or their family members who are directly involved in the trial; 12) The investigator believes that there is no reason for being selected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Granulation tissue coverage; | — |
Secondary
| Measure | Time frame |
|---|---|
| the percentage decrease in wound surface area,wound depth;PUSH score;wound temperature;wound PH;MMP-9 expression;CD34 expression;Ki-67 expression; | — |
Countries
China
Contacts
Public ContactJiang Qixia
Outcome results
None listed