Simplified regional citrate anticoagulation in continuous renal replacement therapy by using a calcium-containing replacement solution: a multicenter randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900022161

Enrollment

Unknown

Registered

2019-03-27

Start date

2019-04-30

Completion date

Unknown

Last updated

2019-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney diseases which are needed RCA-based CRRT therapy

Interventions

Group 1:Calcium-containing replacement solution

Group 2:Calcium-free replacement solution

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients who need renal replacement therapy, such as AKI, ESRD, acute drug or pesticide intoxication, etc.; 2. Haemodynamically stable; 3. Aged between 18 to 70 years old; 4. With written consent form patients.

Exclusion criteria

Exclusion criteria: 1. Patients with citrate anticoagulant contraindications, such as severe liver failure or severe hypercalcemia (>4 mmol/L); 2. Organ transplant patients; 3. Pantients who can not cooperate because of mental illness or other reasons.

Design outcomes

Primary

Measure	Time frame
Hemofilter survival;The percent of patent hemofilters;	—

Secondary

Measure	Time frame
Pre-filter and postfilter ionized calcium levels;urine output;creatinine;eGFR;Mortality;Renal function recovery;	—

Countries

China

Contacts

Public ContactZhang Ling

Nephrology Department, West China Hospital, Sichuan University

zhanglinglzy@163.com+86 18980601985

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026