hypertensive renal injury and hypertensive diabetic renal injury
Conditions
Interventions
Group 1:Quanduzhong capsule and losartan potassium tablets
Group 2:Quanduzhong capsule+osartan-potassium-tablet mimetics
Group 3:Losartan potassium tablets+Quanduzhong-capsule mimetics
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years, male or female; 2. Diagnose with hypertensive renal injury and hypertensive diabetic renal injury; 3. Blood pressure under 120-140/70-90mmHg within one month; 4. Subjects are volunteered to participate in the trial and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Serious hepatorenal insufficiency; 2. 24-hour urine protein >= 2g; 3. Severe cognitive impairment or mental illness; 4. Aphasia; 5. Various types of acute or chronic nephritis; 6. Urinary system infection; 7. Gout; 8. Patients with gastrointestinal lesions or following gastrointestinal tract operation , which may affect drug absorption or excretion, such as gastrointestinal resection, ulcer or gastrointestinal bleeding; 9. Women in gestational and lactational period or those who plan to give birth to a child in the past six months; 10. Have a history of alcoholism or drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urinary albumin/urine creatinine;24-hour urine protein quantification; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;Urinary renal function;AngII, IL-6;fundus examination;Clinical syndrome evaluation;creatinine clearance rate;Urine a1-microglobulin;cystatin C;hs-CRP;HCY;24-hour ambulatory blood pressure; | — |
Countries
China
Contacts
Public ContactHuang Li
Department of Cardiology with integrated traditional Chinese and Western Medicine, China-Japan Friendship Hospital, Chaoyang District, Beijing
Outcome results
None listed