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Effects of individualized PEEP on pulmonary complications and inflammatory factors after laparoscopic surgery: a randomized controlled trial

Effects of individualized PEEP on pulmonary complications and inflammatory factors after laparoscopic surgery: a randomized controlled trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900022135
Enrollment
Unknown
Registered
2019-03-26
Start date
2019-05-01
Completion date
Unknown
Last updated
2019-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pulmonary complications

Interventions

group SG:PEEP 8cmH2O
group CG:Individualized PEEP

Sponsors

Shapingba District People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) for patients undergoing laparoscopic surgery under general anesthesia for 1-2h, endotracheal catheter should be removed after the operation; (2) ASA ? ~ ?; (3) no age limit, no gender limit, body mass index of 18-30 kg/m2; (4) patients voluntarily accepted general anesthesia and participated in this study.

Exclusion criteria

Exclusion criteria: (1) people who are known to be allergic to narcotic drugs or other drugs; (2) history of alcohol or opioid abuse; (3) patients with a history of neuromuscular disease, endocrine system disease, allergy disease, mental disease, severe cardiovascular disease, liver and kidney dysfunction; (4) patients with severe preoperative pulmonary function impairment requiring postoperative respiratory support; (5) the blood loss during the operation is more than 20% of the blood volume of the body weight, and the need for a second operation after the operation; (6) patients who participated in clinical studies of other drugs in the past three months; (7) for any reason, it is not suitable to be included in this study.

Design outcomes

Primary

MeasureTime frame
Postoperative pulmonary complications;SP-A;TNF-a;IL-8;

Countries

China

Contacts

Public ContactFang Ping
849663407@qq.com+86 13808395580

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026