Intrauterine Adhesion
Conditions
Interventions
Study group:Estradiol gel
Control group:estradiol valerate
Sponsors
West China Second University Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: ? Aged 18-45 years; ? Patients undergoing IUA isolation; ? According to the American fertility association (AFS) IUA prognostic classification score, the score was 5 to 12; ? No use of iud or sex hormone drugs in the first 6 months of the study; ? Liver and kidney function, blood triglycerides, activated protein C activity and hypersensitive c-reactive protein were normal; ? Prothrombin, prothrombin fragments 1 and 2, vascular hemophilia factor (VWF) and coagulation function were normal; ? No abnormality of clinical significance was found in ecg examination; ? Patients who agreed to participate in the study and signed an informed consent.
Exclusion criteria
Exclusion criteria: ? Previous IUA surgical treatment history; ? Combined with other reproductive system diseases, such as reproductive system tumors, infections and tuberculosis (including tuberculous and tumorous IUA); ? Breast tumors and breast hyperplasia and other breast diseases; ? Have a history of thrombotic disease, family history or high risk factors of thrombosis; ? Pre-operation B ultrasound monitoring ovulation without ovulation; ? Participate in other research projects in the previous 3 months; ? According to the researcher's judgment, not suitable for the subject of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| endometrial thickness;Menstrual recovery;RI, PI;Incidence of postoperative readhesion;Amount of estradiol and estrone in blood; | — |
Countries
China
Contacts
Public ContactKehui Xu
West China Second University Hospital
Outcome results
None listed