IgA nephropathy
Conditions
Interventions
Placebo Group:Placebo+telmisartan
Experimental group:Flavoured huangqi chifeng granules+telmisartan
Sponsors
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? The diagnosis was IgA nephropathy, and the pathologic reports of renal perforation were reported in all cases. ? No gender limitation, aged 18-70 years. ? Moderate proteinuria(24-hour urinary protein quantity is between 1.0-2.5g)accompanied or not accompanied by microscopic hematuria. ? CKD1-2(GFR=60ml/min/1.73m2). ? TCM syndrome differentiation accords with qi deficiency and blood stasis syndrome as well as wind pathogen and heat toxicity. ? Non-dialysis patients with infection, acidosis, electrolyte disturbance, hypertension and other aggravating factors are effectively controlled and the condition is stable. The BP is between 130-90/80-60mmHg. Potassium is in the normal range. ? Voluntarily accept this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: ? Secondary factors leading to proteinuria, such as purpura nephritis, lupus nephritis. ? Patients who have been treated by glucocorticoid, immunosuppressant, tripterygium wilfordii preparation in three months are not included. ? Having mental illness, infectious disease or pregnancy. ? Patients who have chronic liver disease, myocardial fibrosis or interstitial pulmonary fibrosis are not included. ? Patients with acute renal failure or after renal transplantation are not included. ? Participants who are participating in other interventional clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urine protein quantitation for 24 hours;Urine protein/creatinine;Routine urine; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCM symptom score;Serum IgA/C3;Serum SIgA;Serum creatinine; | — |
Countries
China
Contacts
Public ContactZhang Yu
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed