esophageal cancer
Conditions
Interventions
Group1:chemoradiotherapy
Group 2:Endostar Combined with chemoradiotherapy
Group 3:Hyperthermia Combined with chemoradiotherapy
Group 4:Endostar and hyperthermia Combined with chemoradiotherapy
Sponsors
The Second Affilicated Hosptical of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, male or female; 2. Histopathologically confirmed esophageal squamous cell carcinoma and esophageal adenocarcinoma; 3. Clinical stage II to IVa; 4. Karl's score (> 70); 5. There are measurable lesions (RECIST version 1.1); 6. This treatment must be the first course of treatment; 7. Expected survival =6 months; 8. Laboratory inspections meet the following requirements: WBC = 4.0×10^9/L, neutrophil count = 2.0×10^9/L, PLT = 100×10^9/L; total bilirubin, ALT, AST = 1.25 times the upper limit of normal; PT is within the upper limit of normal value. 9. Participants voluntarily joined the study, signed informed consent; 10. Participants had good compliance and follow-up.
Exclusion criteria
Exclusion criteria: 1. Have a distant metastasis; 2. History of malignancy in other sites; 3. Chemotherapy and chest radiotherapy before the start of the trial; 4. Radiotherapy and chemotherapy contraindications include severe infections or other complications such as myocardial infarction, severe arrhythmia, severe cerebrovascular disease, psychosis and uncontrollable diabetes mellitus; 5. Received target therapies; 6. Haemorrhagic tendencies; 7. There is tracheoesophageal fistulas.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective response rate;disease control rate;progression-free survival;Overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| drug safety;Liver and kidney function; | — |
Countries
China
Contacts
Public ContactLiu Wenqi
The Second Affilicated Hosptical of Guangxi Medical University
Outcome results
None listed