hypospadias
Conditions
Interventions
Patients with circumcision:Nil
Repair of hypospadias patients:Nil
Sponsors
Shanghai Renji Hospital, Shanghai Jiao Tong University, School of Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Diagnosis of hypospadias; 2. Voluntarily sign the informed consent and follow up the time required.
Exclusion criteria
Exclusion criteria: All patients with other genital diseases, including cryptorchidism, chromosomal abnormalities and endocrine function defects, were excluded. Patients with preoperative gene examination, AR receptor gene and SRD5A2 gene mutations and those who had received hormone therapy before surgery were also excluded.The exclusion criteria were an inability to communicate (including impairment of sensorium), an inability to provide informed consent, and mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Methylation of AR gene; | — |
Secondary
| Measure | Time frame |
|---|---|
| CpG island methylation of SRD5A2 gene;Vital signs, cardiac and pulmonary functions, liver and kidney functions; | — |
Countries
China
Contacts
Public ContactYi-Dong Liu
Shanghai Renji Hospital, Shanghai Jiao Tong University, School of Medicine
Outcome results
None listed