The influence of Index of Consciousness guided general anesthesia on postoperative cognitive function in elderly patients: a fMRI study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900022062

Enrollment

Unknown

Registered

2019-03-22

Start date

2019-03-20

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee arthritis

Interventions

Control Group:No

IOC Group:IOC guiding

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: elderly patient(=65 yrs), right handed; undergoing unilateral knee arthroplasty; ASA I-III; preoperative MMSE score>27

Exclusion criteria

Exclusion criteria: Severe cardio-pulmonary deisease, severe hypertension; definite neurological disease (cerebral infarction, intracranial tumour, any history of head trauma); any history of pyschiatric disease and depression; any history of alchohol and drug abuse; any history of severe diabetes, chronic nephropathy, liver disease; any history or family history Alzhiemer's disease; any contraindication of MRI scanning and patient who refuse to be recruited.

Design outcomes

Primary

Measure	Time frame
The incidence of neural network change;	—

Secondary

Measure	Time frame
neuropsychologic test result;Serum CRP level;Serum IL-6 level;Serum IL-1ß level;intraoperative anesthetic agents consumption;postoperative intestinal exhaust time;	—

Countries

China

Contacts

Public ContactTianlong Wang

Xuanwu Hospital of Capital Medical University

w_tl5595@hotmail.com+86 010 83199333

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026