Severe mycoplasma pneumonia
Conditions
Interventions
Sevoflurane group:Induced by inhalation of 8% sevoflurane and remifentanil 1 µ g kg-1, 2 ~ 5% sevoflurane (BIS to 40 µ g) was inhaled during operation, and remifentanil (1 µ g kg- 1 ·min-1) was contin
Propofol group :Induced by remifentanil (1 µ g/ kg-1 and propofol 2 -4 mg /kg-1 , and infusion of propofol (9 /-15 mg/ kg- 1 ·h-1) and remifentanil( 1 µ g/ kg-1) to maintain anesthesia with BIS be
Sponsors
Maternal and Child Health Hospital of Hubei Province
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The inclusion criteria were as follows: (1) aged 2 to 12 years; (2) all the children were examined on admission and the pathogen culture experiment met the diagnostic criteria of mpp; (3) persistent hyperpyrexia (= 38.5 ?), cough, single macrolide antibiotics, no change or progressive aggravation of symptoms and imaging findings, consolidation of lung lobes with atelectasis, or pleural effusion of varying degrees, Serological mp-igm was positive and chest imaging findings were consistent with mycoplasma lobar pneumonia. (4) informed consent.
Exclusion criteria
Exclusion criteria: The exclusion criteria were: (1) immunosuppression, liver and kidney insufficiency, history of cardiovascular and endocrine diseases, (2) allergy to anesthetic and analgesic drugs and use of anesthetic and analgesic drugs within three months; (3) the patients received fiberbronchoscopy and immunoregulatory drugs within three months, and (4) the primary diagnosis of alveolar lavage fluid showed mixed infection of bacteria or respiratory tract viruses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD3+ T cells,CD4+ T cells and CD8+ T cells;Th1 cells (CD3+CD4+IFN-?+)?Th2 cells (CD3+CD4+IL-4+); | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical efficacy and hospitalization time, etc.; | — |
Countries
China
Contacts
Public ContactChen Lin
Outcome results
None listed