Various Tumours
Conditions
Interventions
Group 1:Autologous immunotherapy+Surgical
Group 2:Surgical
Group 3:Autologous immunotherapy+MIT
Group 4:MIT
Group 5:Autologous immunotherapy+general treatment
advance group:general treatment
Sponsors
Mengchao Hepatobiliary Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 80 years, No gender limitation; 2. Primary carcinoma without distal metastasis except with advanced cancer; 3. With at least one measurable tumor indicator; 4. No other tumor; 5. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1; 6. The survival of patients should longer than 3 months, and accept follow-up visit. 7. The hematopoietic function of bone marrow should be normal:White blood cell(WBC) > 4.0×10^9/L,platelet (PLT)> 100×10^9/L,neutrophilic granulocyte(ANC)= 1.5×10^9/L,hemoglobin(HGB) = 90g/L,aspartic transaminase hemoglobin =2.5×upper normal limit(UNL),alanine aminotransferase=2.5×UNL,total bilirubin(TBil) =1.5×UNL,serum creatinine=1.0×UNL, prothrombin time,partial thromboplastin time,Plasma fibrinogen and thrombin time were normal; 8. All the patients volunteer should rule out pregnancy until the follow-up completed. 9. The patients volunteer to join in the trial and sign the informed consents.
Exclusion criteria
Exclusion criteria: 1. Clinical symptoms of metastasis should be exclucive,the group of advanced cancer was not limitted. 2. Activing viral or bacterial infections cannot be controlled with appropriate anti-infective therapy should be exclucive. Except HBV patients. 3. Patients with mental illness or other conditions, such as uncontrollable heart or lung disease, diabetes, etc., or the patients cannot cooperate with the researchers for treatment and monitoring requirements. 4. Active rheumatic disease. 5. Organ transplant. 6. Pregnant or lactating women; Disabilitie persons sprescribed by law (such as:blind, deaf, dumb, mentally retarded, physically disabled) or suffering from mental diseases; Taking drugs or adverse drug abuse and alcohol dependence within 5 years are exclucive also. 7. Participating in or participating in other clinical trials within 1 month; 8. The investigator determines that any factors that the patients are not suitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| security; | — |
Countries
China
Contacts
Public ContactXiaolou Li
Mengchao Hepatobiliary Hospital of Fujian Medical University
Outcome results
None listed