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A multicenter randomized controlled clinical trial for plasmapheresis in the treatment of hyperlipidemic acute pancreatitis

A multicenter randomized controlled clinical trial for plasmapheresis in the treatment of hyperlipidemic acute pancreatitis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900022028
Enrollment
Unknown
Registered
2019-03-21
Start date
2019-04-01
Completion date
Unknown
Last updated
2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hyperlipoidemia acute pancreatitis

Interventions

Experimental Group:therapuetic plasma exchange
control group:Continuous renal replacement therapy

Sponsors

Department of Blood Transfusion, The Second Affiliated Hospital, Army Medical University.
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Acute pancreatitis (AP) with blood TG=11.3 mmol and excludion of other causes including biliary obstruction and alcohol ; or blood TG value between 5.65-11.3mmol / L with chyle-like serum.

Exclusion criteria

Exclusion criteria: (1) A history of cardiopulmonary insufficiency; (2) A history of liver and kidney failure in the past; (3) History of mental illness; (4) Combined with pancreatic cancer; (5) Acute attack on the basis of chronic pancreatitis; (6) Those who did not complete the blood lipid examination within 72 hours after admission; (7) Acute pancreatitis caused by other pathogenic factors, such as biliary stones, micro stones, Oddi sphincter dysfunction, bacterial viral infection, drug-induced acute pancreatitis; (8) A history of severe allergies to plasma, human albumin, and heparin. (9) Informed refusal.

Design outcomes

Primary

MeasureTime frame
Mortality rate;

Secondary

MeasureTime frame
Serum ltriglyceride, TG;Serum amylase;Serum Lipase;modified CT severity index;Ranson evaluation;acute physiology and chronic health evaluation,APACHE-II;modified Marshall evaluation;complication;length of stay; LOS;C reactive protein;Symptom relief time;

Countries

China

Contacts

Public ContactLi Zhongjun

Department of Blood Transfusion, The Second Affiliated Hospital, Army Medical University.

zhongjunli@tmmu.edu.cn+86 13500373622

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026