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Retinal Nerve Fiber Layer Optical Texture Signature as a Novel Biomarker for Detection of Glaucoma Progression

Retinal Nerve Fiber Layer Optical Texture Signature as a Novel Biomarker for Detection of Glaucoma Progression

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900021995
Enrollment
Unknown
Registered
2019-03-19
Start date
2019-04-01
Completion date
Unknown
Last updated
2019-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Interventions

Glaucoma versus normal population:Nil

Sponsors

Research Grant Council, University Grants Committee
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: The inclusion criteria are: age =18 years; best corrected visual acuity (VA) =20/40.

Exclusion criteria

Exclusion criteria: The exclusion criteria are: IOP >30mmHg; only one eye with functional vision; inability to perform reliable VF; pathological myopia (eyes with axial length=26mm with lacquer cracks and chorioretinal atrophy); suboptimal quality of OCT images; previous intraocular surgery other than uncomplicated cataract extraction; and diabetic retinopathy/ maculopathy.

Design outcomes

Secondary

MeasureTime frame
Survival distributions of eyes with progressive decline in RNFL thickness/optical texture signature;Specificities of TPA for detection of progressive decline in RNFL thickness/optical texture signature;Rates of change of VF MD;Age-related rates of change of RNFL thickness/optical texture signature;—

Primary

MeasureTime frame
Hazard ratios for development of VF progression upon detection of progressive decline in RNFL thickness/optical texture signature;—

Countries

China

Contacts

Public ContactLeung Kai Shun Christopher

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong

cksleung@cuhk.edu.hk+852 39435803

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026