colorectal cancer
Conditions
Interventions
Group 1:protective mechanical ventilation combined deep neuromuscular block and low pneumoperitoneum pressure
Group 2:routine mechanical ventilation combined with routine neuromuscular block and pneumoperitoneum pressure
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. patients undergoing elective laparoscopic gastrointestinal tumor resection under general anesthesia; 2. the operation time is expected to last at least 2 hours; 3. years of age at the age of 40~60 (containing); 4. BMI<40kg/m2; 5. ASA<=grade III.
Exclusion criteria
Exclusion criteria: 1. Unable to obtain informed consent to participate in the study; 2. Turn to open, emergency operation; 3. Comply with any of the following: (1) history of any lung and / or abdominal surgery, history of asthma or chronic obstructive pulmonary disease, acute lung injury or acute respiratory distress syndrome, which is expected to require long mechanical ventilation after surgery; (2) persistent hemodynamic instability, intractable shock, and severe heart disease (defined as conforming to the New York Heart Association III or IV cardiac function, or acute coronary syndrome, or persistent ventricular tachycardia); (3) renal insufficiency (SCr is more than 2 times the normal reference range of our hospital, and the urine volume is less than 0.5ml kg-1 H-1, and the glomerular filtration rate is less than 60ml H-1 H-1 or proteinuria); (4) recent immunosuppressive therapy (defined as the need for chemotherapy or radiotherapy) is less than February from the last chemotherapy or radiotherapy; (5) allergy to narcotic drugs, suspected or suspected malignant hyperthermia (family) history; (6) pregnancy (excluded by laboratory examination); (7) any or suspected neuromuscular disease; (8) the physician in charge thinks it is not suitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neutrophil Elastase, NE;Modified Clinical Pulmonary Infection Score, mCPIS;surgical rating scale, SRS; | — |
Countries
China
Contacts
Public ContactYan Tao
Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed