acute ischemic stroke (moderate to severe)
Conditions
Interventions
1:Normal saline + standard treatment
2:MSC + standard treatment
Sponsors
The Third Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-80 years; 2. Within 72h of the initial onset of symptoms; 3. Patients are diagnosed with acute ischemic stroke, according to the guidelines from American Heart Association/ American Stroke Association. 4. Moderate to severe neurological deficits with modified NIH stroke scale (NIHSS) = 6 points, but = 25 points; 5. Patients and their family members are well informed and agree with the related procedures.
Exclusion criteria
Exclusion criteria: 1. Ischemic stroke due to special causes (like coagulopathy, vasculitis); recurrent stroke within 3 months; 2. Hemorrhagic transformation; 3. Severe consciousness disturbance (lethargy, coma); 4. Cerebral hernia; Status epilepticus; 5. Severe medical conditions (like unstable vital signs; multiple organ failure); 6. Severe complications (such as kidney dysfunction, liver dysfunction, severe infection, myocardial infarction, etc.); 7. Presence of other neurological or psychological diseases; 8. Malignant disease like cancer; 9. Hematological disorders: HGB<90g/L, or WBC<4.0×10^9/L, or coagulopathy (PLT<100×10^9/L); 10. Prone to allergies; 11. Pregnant (or possibly pregnant) or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS score;CRP;ESR;immune cell subsets in peripheral blood; | — |
Countries
China
Contacts
Public ContactZhengqi Lu
Department of Neurology, The Third Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed