Acute Respiratory Distress Syndrome
Conditions
Interventions
Routine group:Regular oxygen inhalation
Low pressure group:Noninvasive ventilation
High pressure group:Noninvasive ventilation
Sponsors
First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged older than 18 yearsand younger than 65 years. (2) It conforms to the diagnostic criteria of ARDS defined in Berlin. (3) Respiratory failure due to ARDS requires mechanical ventilation for more than 72 hours. (4) 200 < P/F < 300 mmHg before evacuation of invasive ventilation.
Exclusion criteria
Exclusion criteria: (1) Barotrauma without effective drainage (pneumothorax, mediastinal emphysema, subcutaneous emphysema). (2) Pulmonary underlying diseases (COPD, pulmonary interstitial fibrosis, bronchiectasis, asthma, etc.). (3) Hemodynamic instability (norepinephrine > 0.1ug/kg/min or other vasoactive drugs of the same level). (4) There are definite neuromuscular diseases. (5) Head and face deformity can not cooperate with nasal/mask ventilation. (6) Severe abdominal distension or recent gastrointestinal surgery did not recover. (7) There are many airway secretions and poor airway protection ability. (8) Non-cooperation, can not cooperate with non-invasive ventilation. (9) There are pathologically confirmed malignant tumors. (10) Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Failure rate of treatment within 7 days; | — |
Countries
China
Contacts
Public ContactXu Yonghao
Department of Critical Care Medicine, First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed