Gastric neoplasms requiring laparoscopic surgery
Conditions
Interventions
experimental group T:maintained at a sevoflurane minimum alveolar concentration (MAC) of 0.8±0.1 during the operation.
routine method group C1:routine concentration of sevoflurane
routine method group C2:propofol total intravenous anesthesia
Sponsors
Department of Anesthesiology, Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients scheduled for elective laparoscopic gastric cancer resection. (2) American Society of Anesthesiologists physical staus?-?. (3) Operative time 3h-6h. (4) Age 65-80 years. (5) One day before operation, the (MMSE) score of Mini-mental State Examination was given and the score was = 24. (6) The education level was not less than 6 years. (7) Every patient provided written informed consent.
Exclusion criteria
Exclusion criteria: Patients who meet any of the following criteria will not participate in this study. 1, A long history of taking a large amount of sedative drugs or antidepressants and antianxiety drugs. 2. A history of serious cardiovascular and cerebrovascular diseases and impaired liver and kidney functions. 3. Having an immune system, central nervous system disease, or mental illness. 4. History of severe drug dependence and alcohol abuse . 5. Anaesthesia in the past 3 months, history of surgery. 6. Patients with severe hearing, visual impairment or other reasons can not communicate with the visitor. 7. Patients who are not compliant or unable to communicate with the preoperative test, and could not complete the follow-up after operation. 8. Preoperative biochemical examination suggested renal dysfunction (serum creatinine > 177 µmol/L) or active liver disease. 9. Patients who have had a history of brain surgery. 10. The patient has a history of being sensitive or allergic to the drugs used in this study. 11. The actual weight of the patient was more than ±25% of the standard weight.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time of eye opening and extubation recorded after operation;MMSE and TMT; | — |
Countries
China
Contacts
Public ContactJiebo Wang
Department of Anesthesiology, Fujian Medical University Union Hospital
Outcome results
None listed