Acute renal injury after acute type A of acute aortic dissection
Conditions
Interventions
Early RRT group:the initiation of RRT will be permitted within 6 hours of diagnosis of KDIGO stage 2
Delayed RRT group:the initiation of RRT will be permitted within 8 hours of diagnosis of KDIGO stage 3 or absolute indications for RRT
Sponsors
Beijing Anzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Aged between 18-70 years; (2) The operation was performed within 1 week after acute type A of aortic dissection (3) KDIGO classification stage 2 defined by at least one of the following criteria2-fold increase in serum creatinine from baseline(we used the serum creatinine at hospital admission as baseline serum creatinine) or urinary output = 12 hours; (4) Plasma neutrophil gelatinase–associated lipocalin (NGAL) > 150 ng/mL; (5) Required ICU treatment for at least 3 days.
Exclusion criteria
Exclusion criteria: (1) Pre-existing chronic renal failure (estimated glomerular filtration rate [eGFR] <30 mL/min); (2) previous renal replacement therapy; (3) cardiac arrest without awakening; (4) moribund with expected death within 24 hours; (5) prior renal transplant; (6) pregnancy; (7) hepatorenal syndrome; (8) AKI caused by obstructive etiology; (9) the patient refused clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6;IL-18;IGFBP7;NGAL; | — |
Secondary
| Measure | Time frame |
|---|---|
| lactic acid; | — |
Countries
China
Contacts
Public ContactLiu Nan
Critical Care Unit of Cardiac Surgery, Beijing Anzhen Hospital
Outcome results
None listed