propofol induced body movements during general anesthesia induction in children patients and its potential pre-treatment methods
Conditions
Interventions
Mixed group and Propofol group:Propofol in combination with lidocaine (propofol plus 1ml lidocaine for every 20ml)
Midazolam group and propofol group:Intravenous injection of midazolam 0.1mg/kg was performed 2 minutes before induction
Sufentanil group and propofol group:Sufentanil was intravenously injected at 0.3ug/kg.min in advance
Dexmedetomidine group and propofol group:4ug/kg.h pre-pump dexmedetomidine for 10 minutes
Ketamine group 1 and propofol group:0.5mg/kg ketamine was intravenously injected in advance
Ketamine group 2 and propofol group:0.6mg/kg ketamine was intravenously injected in advance
Ketamine group 3 and propofol group:0.7mg/kg ketamine was intravenously injected in advance
Ketamine group 4 and propofol group:0.8mg/kg ketamine was intravenously injected in advance
Sponsors
The Second Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
4 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. children undergoing elective surgery under general anesthesia; ASA I-II grade; Aged 4-12 years; cooperation with the establishment of placement of intravenous cannulation; capable of a commucation with experimenters; 2. adults undergoing elective surgeryunder general anesthesia; ASA I-II grade; Aged 18-50 years old; surgery is expected no more than 3 h.
Exclusion criteria
Exclusion criteria: 1. Obesity (BMI>30); 2. with mental illness or cerebral disease;movement disorders; 3. heart, lung, liver serious abnormal renal function; 4. with allergy history to drug used or their composition; a history of convulsive seizures or asthma; 5. participating in other clinical trials of patient; 6. Other reasons are not suitable for clinical subjects according to the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence of pain in anesthesia induction;whether there is a body reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| BIS values during anesthesia induction (every 5s);BIS values and time at the beginning of body movement;BIS value and time at the end of body movement;BIS value at the initial of induction;The severaty of body movement; | — |
Countries
China
Contacts
Public ContactSiyuan Li
The Second Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed