Primary ovarian insufficiency
Conditions
Interventions
Low dasage:Ovarian injection
Medium dasage: Ovarian injection
High dosage:Ovarian injection
Sponsors
Institute of Zoology, Chinese Academy of Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Under 40 years of age; 2. Have established regular menstrual cycle, oligomenorrhea / amenorrhea = 4 months; 3. Follicle-Stimulating Hormone(FSH)> 25U/L; 4. Bilateral ovaries are visible by ultrasound; 5. Have fertility requirement, husband has sperms; 6. Willing to sign the Informed Consent Form.
Exclusion criteria
Exclusion criteria: 1. Primary amenorrhea; 2. History of serious drug allergy or allergic constitution; 3. Thrombophlebitis and thrombembolia, past and present; 4. Acute or chronic infection, hematologic disease, angiocardiopathy, pulmonary disease, liver disease, nephropathy, pancreas disease 5. Autoimmune disease, history of severe familial genetic disease, etc. 6. Anatomical abnormality of reproductive system; 7. Contraindications for pregnancy; 8. Spouse azoospermia; 9. HIV+, hepatitis B, C; 10. Thyroid dysfunction; 11. History of previous malignant or ovarian tumors, history of ovarian therapy; 12. Abnormal karyotyping (e.g. turner syndrome, fragile X syndrome); 13. During pregnancy or lactation; 14. Alcohol or other substance abuse; 15. Mental disease, communicate obstruction; 16. Unwilling to comply with follow-up schedule or want to take other treatment during the follow-up period; 17. Attending doctor consider inappropriate to take part in.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vital signs;Adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of antral follicle;Sex hormones;Ovarian volume; | — |
Countries
China
Contacts
Public ContactHongmei Wang
Institute of Zoology, Chinese Academy of Sciences
Outcome results
None listed