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Efficacy and Safety of Thalidomide for the Treatment of Arteriovenous Malformations in Central Nervous System: Pilot Study

Efficacy and Safety of Thalidomide for the Treatment of Arteriovenous Malformations in Central Nervous System: Pilot Study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900021901
Enrollment
Unknown
Registered
2019-03-15
Start date
2019-03-20
Completion date
Unknown
Last updated
2020-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

central nervous system arteriovenous malformations

Interventions

Case series:Oral thalidomide

Sponsors

Xuanwu Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients with central nervous system AVMs who can not who can not benefit from current treatment methods. 2. Patients with central nervous system AVM who can refuse to receive current treatment methods. 3. Written informed consent to participate in the study prior to any study procedures.

Exclusion criteria

Exclusion criteria: 1. Pregnant and lactating female patients. 2. Patients younger than 2 years old. 3. Patients who is preparing for pregnancy. 4. Patients with high risks of thrombogenesis (diabetes, severe infection, malignant tumor, history of thrombogenesis, deep vein catheterization and coagulation disorders) 5. Patients with severe comorbidities of cardiac, pulmonary, renal, liver, hematological diseases 6. Patients who is diagnosed as hereditary hemorrhagic telangiectasia (HHT).

Design outcomes

Primary

MeasureTime frame
radiological change;

Secondary

MeasureTime frame
Pathological test;Neurological outcome;Biomarkers of the blood ;Averse effect;

Countries

China

Contacts

Public ContactHongqi Zhang
xwzhanghq@163.com+86 13011858081

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026