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Pd-1 inhibitors combined with liquid biopsy ctDNA to evaluate the therapeutic effect in patients of advanced unresectable liver cancer

Pd-1 inhibitors combined with liquid biopsy ctDNA to evaluate the therapeutic effect in patients of advanced unresectable liver cancer

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900021897
Enrollment
Unknown
Registered
2019-03-15
Start date
2018-12-01
Completion date
Unknown
Last updated
2019-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hepatocelluar carcinoma

Interventions

Group 1:The Opdivo drug treatment group will be given pd-1 inhibitor treatment once every two weeks. The dose of Opdivo drug is calculated according to 3mg/Kg body weight
Group 2:The Keytruda drug treatment group will be given Keytruda drug treatment once every three weeks, with a dose of 200mg, usage and precautions the same as Opdivo drug.

Sponsors

The Third Affiliated Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) aged 18-75 years old male and female; 2) clinically diagnosed as primary liver cancer; 3) child-pugh level A liver function; 4) PS score 0-1, and the expected survival time is > for 6 months; 5) the subjects volunteered to participate in this study, signed the informed consent form, followed up with good compliance.

Exclusion criteria

Exclusion criteria: 1) suffering from other malignant tumors, organ failure or autoimmune diseases at the same time; 2) receive other immunosuppressive therapy; 3) any social/psychological problems that the researcher has determined are not suitable for the study.

Design outcomes

Primary

MeasureTime frame
Objective response rate;Duration of response;Progression-free survival;Overall survival;

Countries

China

Contacts

Public ContactRuiyun Xu

The Third Affiliated Hospital of Sun Yat-sen University

1798010960@qq.com+86 13809775140

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026