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Effects of different administration methods of methoxamine on neonatal acid-base balance and maternal hemodynamics

Effects of different administration methods of methoxamine on neonatal acid-base balance and maternal hemodynamics

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900021881
Enrollment
Unknown
Registered
2019-03-14
Start date
2019-04-01
Completion date
Unknown
Last updated
2019-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension after spinal anesthesia

Interventions

M:Intramuscular injection of methoxamine
P:Pumping methoxamine

Sponsors

Affiliated Hospital of Xuzhou Medical University, Xuzhou City, Jiangsu Province
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. ASA I-II; 2. Aged 18 to 40 years; 3. Height 150 cm to 180 cm; 4. Body mass index (BMI) is less than 35 kg/m2; 5. Single child, full term; 6. Elective cesarean section.

Exclusion criteria

Exclusion criteria: 1. Combined with cardiovascular and cerebrovascular, respiratory, blood, endocrine, liver and kidney diseases; 2. Maternal complications such as placental abruption, placenta previa, pregnancy-induced hypertension, eclampsia and gestational diabetes; 3. Intraspinal blockade contraindication.

Design outcomes

Primary

MeasureTime frame
Umbilical artery blood PH;blood pressure, heart rate;

Secondary

MeasureTime frame
the doses and times of the remedy use of methoxamine, ephedrine, and atropine;PaO2,PaCO2,BE,Lactate and HCO3- of neonatal umbilical artery and umbilical vein blood and Apgar score of the newborn;the frequency of maternal nausea, vomiting, hypotension, hypertension and bradycardia.;

Countries

China

Contacts

Public ContactXiao HanBing
1045236345@qq.com+86 15996931925

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026