Laryngeal and hypopharyngeal cancer
Conditions
Interventions
Group 2:radical radiotherapy or concurrent chemoradiotherapy
Group 1:surgery+ postoperative adjuvant radiotherapy
Sponsors
Beijing Tongren Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with advanced or advanced throat cancer (local tumor T2-4, any N) who achieved PR after induction chemotherapy in 2-3 cycles [segment reference to the eighth edition of AJCC-TNM staging]; 2. aged 18-75 years old; 3. initial treatment Patients (primary, no surgery, radiotherapy and chemotherapy history); 4. KPS score 80 points and above; 5. blood, heart, lung, liver, kidney and other major organs function is basically normal. WBC=3.5×10^9/L, ANC=1.5×10^9/L, PLT=100×10^9/L, Hb=80g/L, total plasma bilirubin=1.5×the upper limit of normal value, ALT, AST or AKP=2.5× Upper limit of normal value, urea nitrogen, creatinine = 1.25 × upper limit of normal value; 6. improved neck and chest enhancement CT and endoscopy before enrollment; 7. pathological examination before enrollment (differentiation degree, immunological index - Ki-67, EGFR, HPV); 8. Signed informed consent, good compliance.
Exclusion criteria
Exclusion criteria: 1. distant metastasis patients; 2. patients with advanced tracheotomy; 3. patients who can be resected by laser minimally invasive surgery; 4. have uncontrollable seizures, central nervous system disorders or self-knowledge due to mental illness loss; 5. serious controlled infection; 6. major organ dysfunction (including heart, lung, liver, kidney, etc.); 7. can not tolerate general anesthesia; 8. other or two years of malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival;Progression free survival;Laryngeal preserve survival; | — |
Countries
China
Contacts
Public ContactFang Jugao
Beijing Tongren Hospital, Capital Medical University
Outcome results
None listed