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Genome-wide methylation sequencing of non-familial hereditary congenital cataract cases

Genome-wide DNA methylation profiles differences between sporadic congenital cataract patients and control group as measured by bisulfite sequencing

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900021843
Enrollment
Unknown
Registered
2019-03-12
Start date
2019-03-12
Completion date
Unknown
Last updated
2019-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

congenital cataract

Interventions

binocular group:Taking 4 ml of peripheral blood
monocular group:Taking 4 ml of peripheral blood
control group:Taking 4 ml of peripheral blood

Sponsors

Second Affiliated Hospital of Medical College, Zhejiang University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 12 Years

Inclusion criteria

Inclusion criteria: Children with sporadic congenital cataract, aged 0-12 years old.

Exclusion criteria

Exclusion criteria: 1. Having a family history of congenital cataract; 2. Having other serious eye diseases except congenital cataract, amblyopia and refractive error; 3. The medical history indicates that the patient has severe physical diseases, such as heart, lung, liver and kidney dysfunction.

Design outcomes

Primary

MeasureTime frame
Genome-wide DNA methylation level;—

Countries

China

Contacts

Public ContactYao Ke

Second Affiliated Hospital of Medical College, Zhejiang University

xlren@zju.edu.cn+86 0571 87315209

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026