Colon disease
Conditions
Interventions
Control group:Normal saline
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) aged = 65 years old; (2) ASA grade I or II; (3) colonoscopy; (4) signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with known cardiopulmonary function insufficiency; severe cardiovascular disease history (eg, heart failure, severe arrhythmia, etc.); family history of Adams-Stokes syndrome; unstable angina, or patients with myocardial infarction within 6 months; tachycardia/slow history requiring medication and/or resting ECG heart rate 160mmHg and/or diastolic blood pressure >100mmHg after antihypertensive treatment; (3) Craniocerebral injury, possible intracranial hypertension, cerebral artery tumor, cerebrovascular accident history; schizophrenia, mania, insanity, long-term use of psychotropic drugs, history of cognitive dysfunction, or screening MMSE unqualified suggestive of cognitive dysfunction; (4) Respiratory function insufficiency, history of obstructive pulmonary disease, history of asthma, wheezing or sleep apnea syndrome, or history of bronchospasm requiring treatment within 3 months prior to screening or upper respiratory tract infection 1 week before screening, fever, asthma; (5) Have a history of malignant hyperthermia or family history; (6) Have a clinically significant history of abnormal liver, kidney, blood system or metabolic system; (7) Have a history of colectomy; (8) Those with severe infection, trauma or major surgery 4 weeks before screening; or delayed gastric emptying and acute gastrointestinal bleeding; (9) Patients with known hyperalgesia or dysalgesia or refractory cancer pain; (10) Patients with a central nervous system disorder or mental disorder which meet the DSM diagnostic criteria; (11) A patient who is contraindicated to intravenous general anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Propofol dosage;abdominal pain VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamics; | — |
Countries
China
Contacts
Public ContactWangning Shangguan
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Outcome results
None listed