Alzheimer's Disease
Conditions
Interventions
B:lingual gustatory stimulation with favorite taste
C:iTBS and lingual gustatory stimulation with favorite taste
D:sham stimulation
healthy controls:nothing
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
Male
Age
65 Years to 71 Years
Inclusion criteria
Inclusion criteria: 1. All the AD patients fullfill the National Institute of Neurological and Communicative Disorders and Stroke(NINCDS) and Alzheimer ' s Disease and Related Disorders Association(ADRDA)criteria; 2. MoCA< 26;Clinical Dementia Rating(CDR)= 0.5-1.0; 3. aged 65-85 years old; 4. the patients were diagnosed dysphagia through videofluoroscopy Swallowing Study(VFSS),Functional oral intake scale(FOIS)=4 degree.
Exclusion criteria
Exclusion criteria: 1. stroke(ischemia or hemorrhage),traumatic brain injury,radiotheraoy for head and neck cancer,dysphagia from other neural or muscular diseases; 2. With history of psychopathy or neuropathy; 3. lingual atrophy, gustatory diorders; 4. Wernicke aphasia or global aphasia,Hamilton Depression Scale(HAMD)>17,have metal devices or electron device such as heart pacemaker,symptom is unstable,can't finish the test; 5. claustrophobia and refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognitive function;Swallowing function; | — |
Contacts
Public ContactZulin Dou
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed