Rectal Cancer
Conditions
Interventions
Radiotherapy group:PDX model radiotherapy treatment
Radiotherapy and chemotherapy group:PDX model radiotherapy and chemotherapy treatment
Control group:PDX modeling
Sponsors
Shanghai Oriental Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Untreated primary rectal cancer patients diagnosed by histopathological examination; 2. Patients who meet the requirements of preoperative neoadjuvant chemoradiotherapy for rectal cancer and undergo preoperative chemoradiotherapy for colon cancer as planne; 3. Objective tumors that meet RECIST 1.1 criteria and can be evaluated by CT/MRI; 4. KPS score = 60, expected survival time = 3 months; 5. The patient voluntarily signed the informed consent form, with good compliance.
Exclusion criteria
Exclusion criteria: 1. Patients with incomplete clinical data; 2. Those who have not undergone surgery or have unplanned reoperations after surgery; 3. The patient was found to have a second tumor during the treatment and interfered with the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival;Disease free survival;Recurrence rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pathologic complete response;Anal protection rate;Tumor downgrade rate;Adverse reactions;Postoperative complications;NGS; | — |
Countries
China
Contacts
Public ContactChuangang Fu
Shanghai Oriental Hospital
Outcome results
None listed