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Effects of chronic cerebral perfusion insufficiency on amyloid-ß deposition in the brain and its relationship with glymphatic system

Effects of chronic cerebral perfusion insufficiency on amyloid-ß deposition in the brain and its relationship with glymphatic system: A prospective, non-randomized, self-controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900021737
Enrollment
Unknown
Registered
2019-03-07
Start date
2019-03-15
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's disease

Interventions

Severe carotid artery stenosis side and contralateral side:No

Sponsors

The First Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Aged 45–75 years, regardless of sex; (2) Unilateral severe carotid artery stenosis (stenosis= 85%); (3) MRI evidence of no severe cerebral infarcts or white matter demyelination; (4) Cerebral perfusion insufficiency on the side of carotid artery stenosis proved by carotid ultrasound,TCD,CTP,MRI-ALS; (5) Willing to join and provide informed consent.

Exclusion criteria

Exclusion criteria: (1) Can't or not allowed for PET/CT examination; (2) Combined with other central nervous system diseases; (3) Combined with systemic diseases affecting metabolism of Aß, including severe severe liver or kidney dysfunction.

Design outcomes

Primary

MeasureTime frame
Amyloid-ß deposition in the brain;Cerebral metabolic rate of glucose;Cerebral perfusion;Function of glymphatic system;—

Secondary

MeasureTime frame
Plasma Aß40;Plasma Aß42;Plasma sLRP1;Plasma sRAGE;Biochemical testing;Evaluation of cognitive function;APOE genotype;—

Countries

China

Contacts

Public ContactQiumin Qu
quqiumin@126.com+86 13892898562

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026