intestinal microbiota imbalance after colonoscopy
Conditions
Interventions
experimental group:Bifidobacterium Tetragenous Viable Bacteria Tablets
control group:pIacebo
Sponsors
The First Medical Center of The PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Sign informed consent voluntarily; 2. Aged 18 to 75 years, male or female; 3. Outpatients with indications for colonoscopy.
Exclusion criteria
Exclusion criteria: 1. Patient with systemic or local malignancy, or patient who cannot discontinue immunosuppressive agents; 2. Patient with digestive diseases that have a great impact on the study: including inflammatory bowel disease, infectious gastro-intestinal disease, colorectal polyps (size=2cm or quantity>3 or requiring EMR); 3. Fecal occult blood (+) or white blood cells (+); when the fecal occult blood (+), but the colonoscopy results are normal, the patient can be included in the study; 4. Patient with severe psychiatric or psychological disease; 5. Patient with a history of drug abuse or alcohol abuse, or those who drink a lot or take antibiotics in the past month; 6. Patient who is allergic to the study drug; 7. Patient who cannot discontinue the drugs or health products or foods during the trial which can cause diarrhea or affect intestinal microbiota, including cathartics, antibiotics, probiotic-containing drugs/health products/foods/ yogurt, etc. 8. Patient who underwent colonoscopy (or bowel preparation) in the past month; 9.Women who are pregnant or breastfeeding; 10. Patients who are participating or have completed other clinical trials less than 3 months ago; 11. The patient was considered unsuitable for inclusion by other investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of diarrhea within 14 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of symptoms;Changes in intestinal microbiota; | — |
Countries
China
Contacts
Public ContactYunsheng Yang
The General Hospital of People's Liberation Army
Outcome results
None listed